MUS81 Antikörper (AA 283-483)

Produktnummer ABIN7873310

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MUS81 in ELISA und WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für MUS81 Antikörper (AA 283-483) (ABIN7873310)

Target: MUS81 (MUS81 Endonuclease Homolog (MUS81))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUS81 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-MUS81 Antikörper

Bindungsspezifität: AA 283-483

Verwendungszweck: MUS81 Antibody

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids H283-R483) was used as the immunogen for the MUS81 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MUS81 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the MUS81 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MUS81

Target: MUS81 (MUS81 Endonuclease Homolog (MUS81))

Andere Bezeichnung: MUS81

Hintergrund: Crossover junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene. This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.

UniProt: Q96NY9

Pathways: DNA Reparatur