BCL6 Antikörper (AA 28-336)

Produktnummer ABIN7873262

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch BCL6 in WB, FACS und ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für BCL6 Antikörper (AA 28-336) (ABIN7873262)

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Produktdetails anti-BCL6 Antikörper

Bindungsspezifität: AA 28-336

Verwendungszweck: BCL6 Antibody / B-cell lymphoma 6

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human BCL6 recombinant protein (Position: R28-K336) was used as the immunogen for the BCL6 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the BCL6 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the BCL6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu BCL6

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Andere Bezeichnung: BCL6

Hintergrund: The BCL6 antibody targets B-cell lymphoma 6 protein, a transcriptional repressor encoded by the BCL6 gene. B-cell lymphoma 6 plays a pivotal role in germinal center B-cell development, proliferation, and differentiation. As a zinc finger transcription factor, it modulates gene expression by recruiting corepressor complexes to DNA binding sites, silencing target genes involved in DNA damage response, apoptosis, and differentiation. The BCL6 antibody enables detection of this key transcriptional regulator, providing an essential reagent for immunology, oncology, and hematopathology research.

B-cell lymphoma 6 is required for the formation and maintenance of germinal centers during immune responses. It represses genes such as TP53 and PRDM1 to allow B cells to proliferate and undergo somatic hypermutation without triggering apoptosis. The BCL6 antibody allows researchers to visualize this dynamic regulation in lymphoid tissues and cell lines, offering insight into B-cell maturation and immune system adaptation. BCL6 expression is transiently induced during the germinal center stage and subsequently downregulated as cells differentiate into plasma or memory B cells.

Aberrant BCL6 expression is implicated in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma, where chromosomal translocations or mutations disrupt its normal regulation. These alterations lead to constitutive repression of target genes and uncontrolled proliferation. The BCL6 antibody serves as an important diagnostic and research tool for detecting abnormal expression in lymphoma biopsies and assessing therapeutic responses to BCL6 inhibitors. Its use in immunohistochemistry and western blotting allows pathologists to distinguish germinal center B-cell subtypes from activated or memory B cells.

Beyond hematologic malignancies, B-cell lymphoma 6 influences other tissues by modulating inflammation, metabolism, and neural differentiation. In macrophages and T cells, it acts as a transcriptional repressor that controls cytokine production and immune tolerance. The BCL6 antibody enables studies of these non-lymphoid functions, expanding understanding of how this transcription factor integrates immune and metabolic signaling networks. Recent research also links BCL6 to cancer stem cell maintenance and chemoresistance in solid tumors, underscoring its broad biological significance.

NSJ Bioreagents provides the BCL6 antibody as a validated reagent for western blotting, immunofluorescence, and immunohistochemistry. It exhibits strong nuclear staining consistent with the transcriptional role of B-cell lymphoma 6. By enabling reliable detection of this transcription factor, the BCL6 antibody supports research into gene regulation, oncogenesis, and immune development. It remains an indispensable tool for understanding how transcriptional repression orchestrates germinal center biology and how its disruption contributes to cancer pathogenesis.

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus