OSBPL5 Antikörper (AA 26-879)

Produktnummer ABIN7873019

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch OSBPL5 in WB, ELISA, IF, ICC und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für OSBPL5 Antikörper (AA 26-879) (ABIN7873019)

Target: OSBPL5 (Oxysterol Binding Protein-Like 5 (OSBPL5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OSBPL5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Produktdetails anti-OSBPL5 Antikörper

Bindungsspezifität: AA 26-879

Verwendungszweck: OSBPL5 Antibody / Oxysterol-binding protein-related protein 5

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human OSBPL5 recombinant protein (Position: R26-K879) was used as the immunogen for the OSBPL5 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the OSBPL5 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the OSBPL5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu OSBPL5

Target: OSBPL5 (Oxysterol Binding Protein-Like 5 (OSBPL5))

Andere Bezeichnung: OSBPL5

Hintergrund: OSBPL5 antibody detects Oxysterol-binding protein-related protein 5, a lipid transfer protein involved in cholesterol and phospholipid exchange between organelles. OSBPL5 belongs to the oxysterol-binding protein (OSBP) family that mediates lipid homeostasis and endoplasmic reticulum-plasma membrane tethering. The OSBPL5 antibody is used in studies of lipid metabolism, organelle communication, and membrane dynamics.

OSBPL5 is encoded by the OSBPL5 gene located on human chromosome 11q13.1. The protein is approximately 100 kilodaltons and contains a pleckstrin homology (PH) domain, a FFAT motif, and a C-terminal OSBP-like sterol-binding domain. OSBPL5 localizes to membrane contact sites between the endoplasmic reticulum and late endosomes or mitochondria, where it regulates non-vesicular lipid transport.

The OSBPL5 antibody detects a 100 kilodalton band on western blot and exhibits punctate cytoplasmic staining. Functional studies show that OSBPL5 participates in cholesterol redistribution and phosphatidylserine transport, thereby influencing membrane composition and signaling. It also regulates autophagy and mitochondrial dynamics by modulating lipid exchange at organelle interfaces.

OSBPL5 plays roles in metabolism, growth regulation, and reproduction, with high expression in liver, testis, and brain. Dysregulation has been linked to metabolic disorders, including insulin resistance and obesity. NSJ Bioreagents provides a validated OSBPL5 antibody, supporting research into lipid trafficking, membrane homeostasis, and organelle interaction.

UniProt: Q9H0X9