SLC46A3 Antikörper (AA 26-461)

Produktnummer ABIN7873007

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SLC46A3 in ELISA, IHC und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für SLC46A3 Antikörper (AA 26-461) (ABIN7873007)

Target: SLC46A3 (Solute Carrier Family 46, Member 3 (SLC46A3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC46A3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-SLC46A3 Antikörper

Bindungsspezifität: AA 26-461

Verwendungszweck: SLC46A3 Antibody / Solute carrier family 46 member 3

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SLC46A3 recombinant protein (Position: Q26-R461) was used as the immunogen for the SLC46A3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SLC46A3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SLC46A3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SLC46A3

Target: SLC46A3 (Solute Carrier Family 46, Member 3 (SLC46A3))

Andere Bezeichnung: SLC46A3

Hintergrund: SLC46A3 antibody detects Solute carrier family 46 member 3, encoded by the SLC46A3 gene. Solute carrier family 46 member 3 is a lysosomal transporter protein that regulates the uptake and turnover of therapeutic agents and endogenous substrates within lysosomes. SLC46A3 antibody provides researchers with a reliable reagent for studying lysosomal biology, drug metabolism, and transport processes that influence disease and therapy response.

Solute carrier family 46 member 3 is part of the SLC46 family of membrane transporters. Research using SLC46A3 antibody has shown that it localizes to the lysosomal membrane, where it regulates the uptake of antibody-drug conjugates and peptide-linked cytotoxic compounds. By mediating drug catabolism within lysosomes, SLC46A3 directly affects the pharmacokinetics and therapeutic efficacy of targeted cancer treatments.

Studies with SLC46A3 antibody have revealed that loss of SLC46A3 impairs intracellular processing of antibody-drug conjugates, resulting in reduced cytotoxic release and drug resistance. This has identified SLC46A3 as a biomarker for therapeutic response and an important factor in optimizing targeted therapy. In addition to drug processing, SLC46A3 likely contributes to the transport of small molecules essential for lysosomal metabolism and homeostasis.

Dysregulation of SLC46A3 has been linked to cancer biology. Research using SLC46A3 antibody has demonstrated that reduced expression promotes resistance to certain therapies, while elevated expression may enhance drug sensitivity. This dual role emphasizes its importance as both a mechanistic regulator and a predictive biomarker. Further studies suggest possible roles in neurological and metabolic disorders, although these remain under investigation.

SLC46A3 antibody is commonly used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies transporter expression across cancer models, immunohistochemistry demonstrates lysosomal localization in tissue, and immunofluorescence highlights colocalization with lysosomal markers such as LAMP1. These applications make SLC46A3 antibody valuable for therapeutic and cellular transport research.

By supplying validated SLC46A3 antibody reagents, NSJ Bioreagents supports studies into lysosomal transport, drug metabolism, and disease. Detection of Solute carrier family 46 member 3 provides researchers with insight into how lysosomal transporters influence drug efficacy and pathology.

UniProt: Q7Z3Q1