BRSK2 Antikörper (AA 250-736)

Produktnummer ABIN7872927

Der Kaninchen Polyklonal anti-BRSK2 Antikörper wird verwendet zum Nachweis von BRSK2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für BRSK2 Antikörper (AA 250-736) (ABIN7872927)

Target: BRSK2 (BR serine/threonine Kinase 2 (BRSK2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRSK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-BRSK2 Antikörper

Bindungsspezifität: AA 250-736

Verwendungszweck: BRSK2 Antibody / Brain-selective kinase 2

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M250-P736) was used as the immunogen for the BRSK2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the BRSK2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the BRSK2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu BRSK2

Target: BRSK2 (BR serine/threonine Kinase 2 (BRSK2))

Andere Bezeichnung: BRSK2

Hintergrund: BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene. BRSK2 was initially identified through a computer screen of the human genome and shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK2 is expressed in the brain and to a lesser extent in the testes. BRSK2 is a member of the AMP-activated protein kinase subfamily and can be activated by the tumor suppressor kinase LKB1. More recently, it has been shown that both BRSK2 and the related protein BRSK1 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. BRSK2 has also been shown to be an autoantigen in paraneoplastic limbic encephalitis. At least four isoforms of BRSK2 are known to exist.

UniProt: Q8IWQ3