CHGB Antikörper (AA 250-450)

Produktnummer ABIN7872902

Dieser Maus Monoklonal Antikörper detektiert spezifisch CHGB in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für CHGB Antikörper (AA 250-450) (ABIN7872902)

Target: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CHGB Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: CHGB-7756

Produktdetails anti-CHGB Antikörper

Bindungsspezifität: AA 250-450

Verwendungszweck: Chromogranin B Antibody / CHGB / Secretogranin I

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 250-450) from the human protein was used as the immunogen for the Chromogranin B antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Chromogranin B antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Chromogranin B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu CHGB

Target: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Andere Bezeichnung: Chromogranin B

Hintergrund: Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A), chromogranin B (Chr-B, also known as secretogranin I) chromogranin C (also known as secretogranin II or Sg II), secretogranin III (Sg III or SCG3). High levels of Chr-A expression is a characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits Insulin secretion, exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms, the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine, while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Sg III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes.

UniProt: P05060