CHGB Antikörper (AA 250-450)

Produktnummer ABIN7859640

Der Maus Monoklonal anti-CHGB Antikörper wird verwendet zum Nachweis von CHGB in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für CHGB Antikörper (AA 250-450) (ABIN7859640)

Target: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CHGB Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: CHGB-7756

Produktdetails anti-CHGB Antikörper

Bindungsspezifität: AA 250-450

Verwendungszweck: Chromogranin B / CHGB (Neuroendocrine Marker) Antibody

Spezifität: Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A), chromogranin B (Chr-B, also known as secretogranin I) chromogranin C (also known as secretogranin II or Sg II), secretogranin III (Sg III or SCG3). High levels of Chr-A expression is a characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits Insulin secretion, exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms, the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine, while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Sg III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa250-450) of human CHGB protein (exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu CHGB

Target: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Andere Bezeichnung: Chromogranin B

Hintergrund:

CCB peptide, Cg B, CgB, Chgb, SCG1, SCG1_HUMAN, Secretogranin 1, Secretogranin B, Secretogranin I, SgI

Human adrenal gland, kidney, pancreas, cerebellum or stomach.

Molekulargewicht: 76/110kDa

Gen-ID: 1114, 516874

UniProt: P05060