CXCL12 Antikörper (AA 24-99)

Produktnummer ABIN7872728

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CXCL12 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Zebrafisch (Danio rerio).

Kurzübersicht für CXCL12 Antikörper (AA 24-99) (ABIN7872728)

Target: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCL12 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CXCL12 Antikörper

Bindungsspezifität: AA 24-99

Verwendungszweck: Zebrafish Cxcl12 Antibody / Cxcl12a / Cxcl12b

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Cxcl12 recombinant protein (amino acids K24-V99) was used as the immunogen for the Zebrafish Cxcl12 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Cxcl12 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Cxcl12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu CXCL12

Target: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Andere Bezeichnung: Cxcl12

Hintergrund: Cxcl12, also known as stromal cell-derived factor 1, is a chemokine that plays a crucial role in the regulation of cell migration, particularly during embryonic development and immune cell trafficking. In zebrafish, Cxcl12 is essential for the proper guidance of various cell types, including primordial germ cells, neural crest cells, and hematopoietic stem cells.

Cxcl12 signals through its receptor Cxcr4, and this signaling axis is conserved across vertebrates. In zebrafish embryos, Cxcl12 is expressed in defined tissue regions and acts as a chemoattractant, guiding migrating cells to their correct destinations. It is also involved in vascular development, organ positioning, and fin regeneration.

Because of its conserved function and well-characterized roles in developmental and immune processes, zebrafish Cxcl12 is widely used as a model for studying chemokine signaling, stem cell migration, tumor metastasis, and inflammatory responses. It is also a valuable tool in regenerative biology and drug discovery targeting chemokine pathways.

UniProt: Q8AV10

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling