RSRC2 Antikörper (AA 226-434)

Produktnummer ABIN7872410

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RSRC2 in WB, ELISA, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für RSRC2 Antikörper (AA 226-434) (ABIN7872410)

Target: RSRC2 (arginine/serine-Rich Coiled-Coil 2 (RSRC2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RSRC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-RSRC2 Antikörper

Bindungsspezifität: AA 226-434

Verwendungszweck: RSRC2 Antibody / Arginine/serine-rich coiled-coil protein 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human RSRC2 recombinant protein (Position: F226-V434) was used as the immunogen for the RSRC2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the RSRC2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the RSRC2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu RSRC2

Target: RSRC2 (arginine/serine-Rich Coiled-Coil 2 (RSRC2))

Andere Bezeichnung: RSRC2

Hintergrund: RSRC2 antibody detects Arginine/serine-rich coiled-coil protein 2, a nuclear splicing factor that regulates pre-mRNA processing and alternative splicing. The UniProt recommended name is Arginine/serine-rich coiled-coil protein 2 (RSRC2). This serine/arginine-rich (SR) protein family member modulates spliceosome assembly and mRNA maturation, influencing gene expression across multiple tissues.

Functionally, RSRC2 antibody identifies a 477-amino-acid protein localized to nuclear speckles where it associates with splicing machinery components. RSRC2 facilitates exon recognition and splice site selection through interactions with U2AF and SR proteins, ensuring accurate pre-mRNA splicing. It also acts as a transcriptional co-regulator linking splicing to gene expression control.

The RSRC2 gene is located on chromosome 12q24.31 and is widely expressed, with enrichment in brain, heart, and testis. RSRC2 activity supports tissue-specific splicing patterns essential for cellular differentiation and development. It dynamically redistributes within the nucleus in response to transcriptional and stress signals, reflecting its role in gene expression regulation.

Pathologically, RSRC2 dysregulation has been implicated in neurodegenerative disease, cancer, and cardiovascular disorders. Altered RSRC2 expression disrupts mRNA splicing fidelity and may affect tumor suppressor or oncogene expression. Research using RSRC2 antibody aids in studies of RNA processing, splicing regulation, and gene expression control.

RSRC2 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect splicing regulators and nuclear speckle proteins. NSJ Bioreagents offers RSRC2 antibody reagents optimized for RNA biology, molecular genetics, and transcriptional regulation research.

Structurally, Arginine/serine-rich coiled-coil protein 2 contains SR repeats mediating protein interactions and a coiled-coil region that promotes nuclear localization and complex formation. This antibody enables detailed analysis of RSRC2's role in co-transcriptional mRNA processing and cellular homeostasis.

UniProt: Q7L4I2