Rekombinanter Decorin Antikörper (AA 212-336)

Produktnummer ABIN7872208

Der Kaninchen Monoklonal anti-Decorin Antikörper (Klon DCN-8715R) (ABIN7872208) detektiert spezifisch Decorin in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter Decorin Antikörper (AA 212-336) (ABIN7872208)

Target: Decorin (DCN)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Decorin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: DCN-8715R

Produktdetails anti-Decorin Antikörper

Bindungsspezifität: AA 212-336

Verwendungszweck: Recombinant Decorin Antibody / DCN

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant human Decorin protein fragment (within amino acids 212-336) was used as the immunogen for the recombinant Decorin antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant Decorin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the recombinant Decorin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Decorin

Target: Decorin (DCN)

Andere Bezeichnung: Decorin

Hintergrund: Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGFbeta and is a direct or indirect negative modulator of TGFbeta synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-gamma and TNFAlpha may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope.

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process