Decorin Antikörper (AA 212-336)

Produktnummer ABIN7872206

Dieser Maus Monoklonal Antikörper detektiert spezifisch Decorin in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Decorin Antikörper (AA 212-336) (ABIN7872206)

Target: Decorin (DCN)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Decorin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: DCN-3521

Produktdetails anti-Decorin Antikörper

Bindungsspezifität: AA 212-336

Verwendungszweck: Decorin Antibody

Aufreinigung: Protein G affinity

Immunogen: A recombinant human Decorin partial protein (within amino acids 212-336) was used as the immunogen for the Decorin antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Decorin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Decorin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Decorin

Target: Decorin (DCN)

Andere Bezeichnung: Decorin

Hintergrund: Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGFå°3/4 and is a direct or indirect negative modulator of TGFå°3/4 synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-c° and TNFä1/4a may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. The human Decorin gene maps to chromosome 12q21.33 and encodes a 359 amino acid protein.

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process