Decorin Antikörper (AA 212-336)

Produktnummer ABIN7872204

Der Maus Monoklonal anti-Decorin Antikörper wird verwendet zum Nachweis von Decorin in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Decorin Antikörper (AA 212-336) (ABIN7872204)

Target: Decorin (DCN)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Decorin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: DCN-3523

Produktdetails anti-Decorin Antikörper

Bindungsspezifität: AA 212-336

Verwendungszweck: Decorin Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: A human recombinant partial protein (amino acids 212-336) was used as the immunogen for the Decorin antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Decorin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Decorin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Decorin

Target: Decorin (DCN)

Andere Bezeichnung: Decorin

Hintergrund: Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGF and is a direct or indirect negative modulator of TGF synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN- and TNF may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. The human Decorin gene maps to chromosome 12q21.33 and encodes a 359 amino acid protein.

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process