Rekombinanter Decorin Antikörper (AA 200-359)

Produktnummer ABIN7871980

Der Maus Monoklonal anti-Decorin Antikörper (Klon rDCN-9075) (ABIN7871980) detektiert spezifisch Decorin in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter Decorin Antikörper (AA 200-359) (ABIN7871980)

Target: Decorin (DCN)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Decorin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: RDCN-9075

Produktdetails anti-Decorin Antikörper

Bindungsspezifität: AA 200-359

Verwendungszweck: Recombinant DCN Antibody / Decorin (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant human Decorin protein fragment (within amino acids 200-359) was used as the immunogen for the recombinant DCN antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant DCN antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the recombinant DCN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Decorin

Target: Decorin (DCN)

Andere Bezeichnung: DCN

Hintergrund: Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGFbeta and is a direct or indirect negative modulator of TGFbeta synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-gamma and TNFAlpha may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope.

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process