IDO2 Antikörper (AA 200-350)

Produktnummer ABIN7871971

Der Maus Monoklonal anti-IDO2 Antikörper (Klon IDO2-2639) (ABIN7871971) detektiert spezifisch IDO2 in ELISA und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für IDO2 Antikörper (AA 200-350) (ABIN7871971)

Target: IDO2 (Indoleamine 2,3-Dioxygenase 2 (IDO2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IDO2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: IDO2-2639

Produktdetails anti-IDO2 Antikörper

Bindungsspezifität: AA 200-350

Verwendungszweck: INDOL1 Antibody / IDO2

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 200-350 was used as the immunogen for the INDOL1 antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the INDOL1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the INDOL1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu IDO2

Target: IDO2 (Indoleamine 2,3-Dioxygenase 2 (IDO2))

Andere Bezeichnung: INDOL1

Hintergrund: IDO2 is a presumptive immunomodulatory gene based on its close structural relationship to IDO1 and its expression in a variety of antigen-presenting cell types. Both IDO1 and IDO2 will catabolize tryptophan to kynurenine. Biochemical studies indicate that both enzymes are similarly robust in catabolic activity, although the in vitro conditions required for IDO2 to manifest the same level of activity differ somewhat from IDO1. However, whether IDO2 is active as a tryptophan catabolizing enzyme in human dendritic cells has been disputed. Further work is needed to conclusively determine that IDO1 and IDO2 are similar in their preference for substrates and reaction pathways to generate product. A non-redundant function for IDO2 relative to IDO1 is suggested by their rather distinct expression patterns and response to extracellular stimuli.

UniProt: Q6ZQW0