IDO2 Antikörper (AA 200-350)

Produktnummer ABIN7126294

Der Maus Monoklonal anti-IDO2 Antikörper (Klon IDO2-2638) (ABIN7126294) detektiert spezifisch IDO2 in WB, ELISA und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für IDO2 Antikörper (AA 200-350) (ABIN7126294)

Target: IDO2 (Indoleamine 2,3-Dioxygenase 2 (IDO2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IDO2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Klon: IDO2-2638

Produktdetails anti-IDO2 Antikörper

Bindungsspezifität: AA 200-350

Verwendungszweck: IDO2 / Indoleamine 2,3-dioxygenase 2 Antibody

Spezifität: IDO2 is a presumptive immunomodulatory gene based on its close structural relationship to IDO1 and its expression in a variety of antigen-presenting cell types. Both IDO1 and IDO2 will catabolize tryptophan to kynurenine. Biochemical studies indicate that both enzymes are similarly robust in catabolic activity, although the in vitro conditions required for IDO2 to manifest the same level of activity differ somewhat from IDO1. However, whether IDO2 is active as a tryptophan catabolizing enzyme in human dendritic cells has been disputed. Further work is needed to conclusively determine that IDO1 and IDO2 are similar in their preference for substrates and reaction pathways to generate product. A non-redundant function for IDO2 relative to IDO1 is suggested by their rather distinct expression patterns and response to extracellular stimuli.

Kreuzreaktivität (Details): Human.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 200-350) of human IDO2 protein (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order antibody without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human placenta or liver.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide store at 2 to 8 °C. Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu IDO2

Target: IDO2 (Indoleamine 2,3-Dioxygenase 2 (IDO2))

Andere Bezeichnung: IDO2

Hintergrund:

3-dioxygenase 2, 3-dioxygenase-like protein 1, EC 1.13.11., INDOL 1, Indoleamine 2, Indoleamine 2,3 dioxygenase 2, Indoleamine 2,3 dioxygenase like 1 protein, Indoleamine pyrrole 2,3 dioxygenase like 1, Indoleamine-pyrrole 2

Human placenta or liver. 3T3 cells

Molekulargewicht: 47kDa

Gen-ID: 169355, 676257

UniProt: Q6ZQW0