Rekombinanter Syndecan 1 Antikörper (AA 200-300)

Produktnummer ABIN7871952

Der Kaninchen Monoklonal anti-Syndecan 1 Antikörper wird verwendet zum Nachweis von Syndecan 1 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Rekombinanter Syndecan 1 Antikörper (AA 200-300) (ABIN7871952)

Target: Syndecan 1 (SDC1)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Syndecan 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: SDC1-4378R

Produktdetails anti-Syndecan 1 Antikörper

Bindungsspezifität: AA 200-300

Verwendungszweck: Recombinant Syndecan-1 Antibody / CD138 (azide and preservative free)

Aufreinigung: Protein A affinity chromatography

Immunogen: A portion of amino acids 200-300 from the human protein was used as the immunogen for the recombinant Syndecan-1 antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant Syndecan-1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant Syndecan-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Syndecan 1

Target: Syndecan 1 (SDC1)

Andere Bezeichnung: Syndecan-1

Hintergrund: CD138, also designated syndecan-1, is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. The syndecans main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. Under normal conditions CD138/Syndecan-1 is predominantly expressed on mature plasma cells and early preB-cells, while other haematolymphoid cells are negative. Various types of epithelial cells are also CD138/Syndecan-1 positive. Squamous epithelial cells show strong membranous and some cytoplasmic staining, except for the mature superficial squamous epithelial cells which are unstained. Mature mesenchymal and neural tissues are not stained. Among haematolymphoid neoplasms, it is expressed in practically all cases of plasma cell malignancies. Among non-haematolymphoid neoplasms the expression of CD138 is found in various types of carcinoma. In the following, the large majority of cases is CD138 positive: skin squamous cell carcinoma and basal cell carcinoma, colorectal adenocarcinoma, cholangiocarcinoma, transitional cell carcinoma, endometrial adenocarcinoma, ductal and lobular breast carcinoma, hepatocellular carcinoma, renal cell carcinoma, and lung adenocarcinoma. CD138/Syndecan-1 is a very sensitive and specific marker for identification of plasma cells and plasma cell differentiation within haematolymphoid tissues in benign and neoplastic conditions.

UniProt: P18827

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Lipid Metabolism