PGLYRP2 Antikörper (AA 198-524)

Produktnummer ABIN7871753

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PGLYRP2 in ELISA, WB und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für PGLYRP2 Antikörper (AA 198-524) (ABIN7871753)

Target: PGLYRP2 (Peptidoglycan Recognition Protein 2 (PGLYRP2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PGLYRP2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-PGLYRP2 Antikörper

Bindungsspezifität: AA 198-524

Verwendungszweck: PGLYRP2 Antibody / Peptidoglycan recognition protein 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human PGLYRP2 recombinant protein (Position: D198-Q524) was used as the immunogen for the PGLYRP2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PGLYRP2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PGLYRP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PGLYRP2

Target: PGLYRP2 (Peptidoglycan Recognition Protein 2 (PGLYRP2))

Andere Bezeichnung: PGLYRP2

Hintergrund: PGLYRP2 antibody detects N-acetylmuramoyl-L-alanine amidase (also known as Peptidoglycan recognition protein 2), a secreted pattern-recognition enzyme involved in innate immunity. Encoded by the PGLYRP2 gene on chromosome 19q13.12, this protein belongs to the peptidoglycan recognition protein (PGRP) family, which binds and hydrolyzes bacterial peptidoglycan to modulate immune responses. PGLYRP2 contains a conserved amidase domain that cleaves the lactylamide bond between N-acetylmuramic acid and L-alanine in bacterial cell walls, leading to peptidoglycan degradation and reduced inflammatory potential. It acts as a first-line defense mechanism in epithelial barriers such as the liver and intestinal mucosa.

PGLYRP2 is secreted primarily by the liver into the bloodstream, where it functions as a circulating peptidoglycan hydrolase. It neutralizes proinflammatory bacterial components, preventing systemic immune activation. In the gut, PGLYRP2 maintains microbiota balance by degrading bacterial fragments that would otherwise trigger toll-like receptor signaling. Genetic studies have associated PGLYRP2 variants with inflammatory bowel disease and asthma, highlighting its role in mucosal immune tolerance. The protein's enzymatic activity also protects against bacterial sepsis by reducing peptidoglycan-induced cytokine production.

The PGLYRP2 antibody is widely used in immunology, microbiology, and liver biology research to study antimicrobial defense and immune modulation. Western blot analysis typically identifies a 62 kilodalton band corresponding to full-length PGLYRP2, while immunohistochemistry reveals cytoplasmic and secretory vesicle localization in hepatocytes and epithelial cells. This antibody supports characterization of innate immune pathways and microbiota interactions. Dysregulation of PGLYRP2 expression can lead to excessive inflammation or increased bacterial susceptibility.

Mechanistically, PGLYRP2 differs from other PGRPs by possessing amidase enzymatic activity rather than bactericidal or signaling roles. It cooperates with PGLYRP1, PGLYRP3, and PGLYRP4 in forming an integrated host defense network. NSJ Bioreagents provides the PGLYRP2 antibody validated for its applications, ensuring reliable detection in studies of innate immunity, microbial recognition, and liver defense mechanisms.

UniProt: Q96PD5

Pathways: Activation of Innate immune Response, Glycosaminoglycan Metabolic Process