SUV420H2/KMT5C Antikörper (AA 195-220)

Produktnummer ABIN7871703

Der Kaninchen Polyklonal anti-SUV420H2/KMT5C Antikörper wird verwendet zum Nachweis von SUV420H2/KMT5C in Proben von Maus und Human. Er wurde validiert für WB und FACS.

Kurzübersicht für SUV420H2/KMT5C Antikörper (AA 195-220) (ABIN7871703)

Target: SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))

Reaktivität: Maus, Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUV420H2/KMT5C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-SUV420H2/KMT5C Antikörper

Bindungsspezifität: AA 195-220

Verwendungszweck: KMT5C Antibody / SUV420H2

Immunogen: A portion of amino acids 195-220 from the human protein was used as the immunogen for the KMT5C antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the KMT5C antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Aliquot the KMT5C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu SUV420H2/KMT5C

Target: SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))

Andere Bezeichnung: KMT5C

Hintergrund: KMT5C, also called Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 and Suv4-20h2, belongs to a family of proteins called lysine methyltransferases, which are enzymes that play a key role in the modification of histone proteins. Histones are proteins that help package and organize DNA in the nucleus of a cell, and modifications to these proteins can have profound effects on gene expression. Studies have shown that KMT5C specifically targets histone H4 lysine 20 (H4K20) for methylation, which has been linked to the regulation of gene transcription and DNA replication. Dysregulation of this process has been implicated in various diseases, including cancer and developmental disorders. In cancer, aberrant expression of KMT5C has been observed in several tumor types, and its overexpression has been associated with poor prognosis. Mutations in the KMT5C gene have been linked to developmental disorders, such as intellectual disability and autism spectrum disorders. These findings highlight the importance of KMT5C in brain development and function, and provide new insights into the underlying mechanisms of these conditions.

UniProt: Q86Y97