Rekombinanter STING/TMEM173 Antikörper (AA 190-290)

Produktnummer ABIN7871636

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch STING/TMEM173 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter STING/TMEM173 Antikörper (AA 190-290) (ABIN7871636)

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser STING/TMEM173 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: STING1-8129R

Produktdetails anti-STING/TMEM173 Antikörper

Bindungsspezifität: AA 190-290

Verwendungszweck: MITA Antibody / Mediator of IRF3 activation / STING1 / ERIS (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the MITA antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MITA antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the MITA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu STING/TMEM173

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Andere Bezeichnung: MITA

Hintergrund: TMEM173 (transmembrane protein 173), also called MITA (Mediator of IRF3 activation), STING1 and ERIS, is a 379 amino acid protein encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6 % of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

UniProt: Q86WV6

Pathways: Activation of Innate immune Response