Rekombinanter STING/TMEM173 Antikörper (AA 190-290)

Produktnummer ABIN7871635

Der Kaninchen Monoklonal anti-STING/TMEM173 Antikörper (Klon STING1-8187R) (ABIN7871635) detektiert spezifisch STING/TMEM173 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter STING/TMEM173 Antikörper (AA 190-290) (ABIN7871635)

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser STING/TMEM173 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: STING1-8187R

Produktdetails anti-STING/TMEM173 Antikörper

Bindungsspezifität: AA 190-290

Verwendungszweck: ERIS Antibody / Endoplasmic reticulum interferon stimulator / STING1

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the ERIS antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the STING1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the STING1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu STING/TMEM173

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Andere Bezeichnung: ERIS

Hintergrund: TMEM173 (transmembrane protein 173), also called STING1 and ERIS (Endoplasmic reticulum interferon) is a 379 amino acid protein encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6 % of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

UniProt: Q86WV6

Pathways: Activation of Innate immune Response