C5 Antikörper (AA 19-294)

Produktnummer ABIN7871583

Der Kaninchen Polyklonal anti-C5 Antikörper wird verwendet zum Nachweis von C5 in Proben von Maus und Ratte. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für C5 Antikörper (AA 19-294) (ABIN7871583)

Target: C5 (Complement Component 5 (C5))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-C5 Antikörper

Bindungsspezifität: AA 19-294

Verwendungszweck: C5B Antibody / Complement C5B

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant mouse protein (amino acids Q19-D294) was used as the immunogen for the C5B antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the C5B antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the C5B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu C5

Target: C5 (Complement Component 5 (C5))

Andere Bezeichnung: C5B

Hintergrund: Complement component 5 is a protein that in humans is encoded by the C5 gene. This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model.

UniProt: P06684

Pathways: Komplementsystem, Carbohydrate Homeostasis