FSHB Antikörper (AA 19-130)

Produktnummer ABIN7871556

Der Kaninchen Polyklonal anti-FSHB Antikörper wird verwendet zum Nachweis von FSHB in Proben von Zebrafisch (Danio rerio). Er wurde validiert für WB und IHC (p).

Kurzübersicht für FSHB Antikörper (AA 19-130) (ABIN7871556)

Target: FSHB (Follicle Stimulating Hormone, beta Polypeptide (FSHB))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FSHB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FSHB Antikörper

Bindungsspezifität: AA 19-130

Verwendungszweck: Zebrafish Fshb Antibody / Follicle stimulating hormone beta

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Fshb recombinant protein (amino acids E19-H130) was used as the immunogen for the Zebrafish Fshb antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Fshb antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Fshb antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu FSHB

Target: FSHB (Follicle Stimulating Hormone, beta Polypeptide (FSHB))

Andere Bezeichnung: Fshb

Hintergrund: Follicle-stimulating hormone (FSH) is a key glycoprotein hormone involved in the regulation of reproductive processes across vertebrate species. It is composed of a common alpha subunit and a hormone-specific beta subunit, with the beta subunit (Fshb) conferring biological specificity. In zebrafish (Danio rerio), the fshb gene encodes the beta subunit of FSH and is expressed in gonadotrope cells of the anterior pituitary.

Zebrafish Fshb plays a crucial role in the development and maturation of gametes, particularly in promoting folliculogenesis in females and spermatogonial proliferation in males. Its expression and secretion are primarily regulated by gonadotropin-releasing hormone (GnRH) and modulated by feedback from sex steroids and other endocrine factors within the hypothalamic-pituitary-gonadal (HPG) axis.

During zebrafish development, fshb expression becomes evident post-embryonically and increases with sexual maturation. Functional studies have shown that Fshb is essential for early-stage follicle development and the onset of puberty, while also contributing to basal steroidogenesis in the gonads.

Given the genetic accessibility and transparency of zebrafish, the fshb gene and its protein product are commonly used in reproductive biology, toxicology, and endocrine disruption studies. Zebrafish Fshb shares structural and functional homology with its mammalian counterparts, making it a valuable model for exploring conserved mechanisms of vertebrate reproduction.

UniProt: Q6TCF7

Pathways: Peptide Hormone Metabolism, Hormone Activity, C21-Steroid Hormone Metabolic Process