GBA3 Antikörper (AA 17-469)

Produktnummer ABIN7871235

Der Kaninchen Polyklonal anti-GBA3 Antikörper wird verwendet zum Nachweis von GBA3 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und ELISA.

Kurzübersicht für GBA3 Antikörper (AA 17-469) (ABIN7871235)

Target: GBA3 (Glucosidase, Beta, Acid 3 (Cytosolic) (GBA3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GBA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-GBA3 Antikörper

Bindungsspezifität: AA 17-469

Verwendungszweck: GBA3 Antibody / Glucosidase beta acid 3 / Cytosolic beta-glucosidase

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human GBA3 recombinant protein (Position: Q17-L469) was used as the immunogen for the GBA3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GBA3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the GBA3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu GBA3

Target: GBA3 (Glucosidase, Beta, Acid 3 (Cytosolic) (GBA3))

Andere Bezeichnung: GBA3

Hintergrund: GBA3 antibody detects Cytosolic beta-glucosidase, encoded by the GBA3 gene on chromosome 4p15.33. GBA3 antibody is commonly used in carbohydrate metabolism, detoxification, and nutrition-related research. GBA3 is a cytosolic glycoside hydrolase that catalyzes the hydrolysis of beta-glycosidic bonds in various substrates, including plant-derived glycosides and dietary glucosides. Unlike lysosomal beta-glucosidases, GBA3 operates in the cytosol, processing exogenous and endogenous compounds.

Structurally, GBA3 is a ~54 kDa protein belonging to the glycosyl hydrolase family 1 (GH1). It contains a conserved catalytic domain with a (beta/alpha)8 barrel fold that accommodates diverse glycoside substrates. GBA3 is widely expressed in liver, kidney, and intestine, where it contributes to detoxification and carbohydrate processing.

Functionally, GBA3 hydrolyzes beta-glycosidic bonds in compounds such as cyanogenic glycosides and flavonoid glucosides. This activity detoxifies plant-derived compounds and releases bioactive aglycones. GBA3 also metabolizes certain drugs and xenobiotics, influencing pharmacokinetics. Researchers use GBA3 antibody to study carbohydrate metabolism, dietary compound processing, and xenobiotic metabolism.

Clinically, GBA3 activity influences metabolism of dietary compounds and may impact drug responses. Although GBA3 deficiency is not associated with a defined Mendelian disorder, variation in GBA3 may affect nutrition, pharmacology, and detoxification capacity. Because beta-glucosidases have roles in metabolic disease and cancer, GBA3 has been explored as a potential biomarker. NSJ Bioreagents provides GBA3 antibody to support research in nutrition, toxicology, and carbohydrate metabolism.

Experimentally, GBA3 antibody is applied in western blotting to detect the ~54 kDa protein, in immunohistochemistry to study expression in liver and intestine, and in enzymatic assays to confirm substrate specificity. Co-immunoprecipitation with GBA3 antibody helps identify partners in carbohydrate and xenobiotic metabolism pathways.

UniProt: Q9H227