IRF4 Antikörper (AA 163-419)

Produktnummer ABIN7871126

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch IRF4 in WB, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für IRF4 Antikörper (AA 163-419) (ABIN7871126)

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-IRF4 Antikörper

Bindungsspezifität: AA 163-419

Verwendungszweck: Interferon regulatory factor 4 Antibody / IRF4 / MUM1

Aufreinigung: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids A163-Q419) was used as the immunogen for the Interferon regulatory factor 4 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Interferon regulatory factor 4 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Interferon regulatory factor 4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu IRF4

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Andere Bezeichnung: Interferon regulatory factor 4

Hintergrund: Interferon regulatory factor 4 (IRF4), also known as Multiple myeloma oncogene 1 (MUM1), is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.

UniProt: Q15306

Pathways: Chromatin Binding