PCBP1 Antikörper (AA 152-268)

Produktnummer ABIN7870977

Der Kaninchen Polyklonal anti-PCBP1 Antikörper wird verwendet zum Nachweis von PCBP1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IHC (p) und FACS.

Kurzübersicht für PCBP1 Antikörper (AA 152-268) (ABIN7870977)

Target: PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-PCBP1 Antikörper

Bindungsspezifität: AA 152-268

Verwendungszweck: PCBP1 Antibody

Aufreinigung: Affinity purified

Immunogen: A human recombinant partial protein (amino acids P152-K268) was used as the immunogen for the PCBP1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PCBP1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PCBP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PCBP1

Target: PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))

Andere Bezeichnung: PCBP1

Hintergrund: Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene. This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

UniProt: Q15365