SOCS3 Antikörper (AA 13-225)

Produktnummer ABIN7870459

Der Kaninchen Polyklonal anti-SOCS3 Antikörper (ABIN7870459) detektiert spezifisch SOCS3 in WB, ELISA und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für SOCS3 Antikörper (AA 13-225) (ABIN7870459)

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-SOCS3 Antikörper

Bindungsspezifität: AA 13-225

Verwendungszweck: SOCS3 Antibody

Aufreinigung: Affinity purified

Immunogen: A human recombinant partial protein (amino acids S13-L225) was used as the immunogen for the SOCS3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SOCS3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SOCS3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Andere Bezeichnung: SOCS3

Hintergrund: SOCS3 (Suppressor of cytokine signaling 3) is a protein that in humans is encoded by the SOCS3 gene. SOCS3 is transiently expressed by multiple cell lineages within the immune system and functions predominantly as a negative regulator of cytokines that activate the JAK-STAT3 pathway. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

UniProt: O14543

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus, Hepatitis C