Glutathione Peroxidase 1 Antikörper (AA 13-203)

Produktnummer ABIN7870458

Der Kaninchen Polyklonal anti-Glutathione Peroxidase 1 Antikörper wird verwendet zum Nachweis von Glutathione Peroxidase 1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA und IHC (p).

Kurzübersicht für Glutathione Peroxidase 1 Antikörper (AA 13-203) (ABIN7870458)

Target: Glutathione Peroxidase 1 (GPX1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutathione Peroxidase 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Glutathione Peroxidase 1 Antikörper

Bindungsspezifität: AA 13-203

Verwendungszweck: Glutathione Peroxidase 1 Antibody / GPX1

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids A13-A203) was used as the immunogen for the Glutathione Peroxidase 1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Glutathione Peroxidase 1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Glutathione Peroxidase 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Glutathione Peroxidase 1

Target: Glutathione Peroxidase 1 (GPX1)

Andere Bezeichnung: Glutathione Peroxidase 1

Hintergrund: Glutathione peroxidase 1, also known as, GPX-1 is an enzyme that in humans is encoded by the GPX1 gene. It is mapped to 3p21.31. This gene encodes a member of the glutathione peroxidase family, consisting of eight known glutathione peroxidases (Gpx1-8) in humans. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. It has been reported that the protein encoded by this gene protects from CD95-induced apoptosis in cultured breast cancer cells and inhibits 5-lipoxygenase in blood cells, and its overexpression delays endothelial cell growth and increases resistance to toxic challenges. GPX1 is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA.

UniProt: P07203

Pathways: Thyroid Hormone Synthesis, Sensory Perception of Sound, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom