Histone H2A Antikörper (AA 115-143)

Produktnummer ABIN7870200

Der Maus Monoklonal anti-Histone H2A Antikörper wird verwendet zum Nachweis von Histone H2A in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für Histone H2A Antikörper (AA 115-143) (ABIN7870200)

Target: Histone H2A

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Histone H2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 938CT5-1-1

Produktdetails anti-Histone H2A Antikörper

Bindungsspezifität: AA 115-143

Verwendungszweck: Histone H2AX Antibody / H2AFX

Aufreinigung: Protein G affinity

Immunogen: A portion of amino acids 115-143 from the human protein was used as the immunogen for the Histone H2AX antibody.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Histone H2AX antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Histone H2AX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Histone H2A

Target: Histone H2A

Hintergrund: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

UniProt: P16104