SLFN11 Antikörper (AA 114-794)

Produktnummer ABIN7870195

Der Kaninchen Polyklonal anti-SLFN11 Antikörper (ABIN7870195) detektiert spezifisch SLFN11 in ELISA, WB, FACS und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für SLFN11 Antikörper (AA 114-794) (ABIN7870195)

Target: SLFN11 (Schlafen Family Member 11 (SLFN11))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLFN11 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SLFN11 Antikörper

Bindungsspezifität: AA 114-794

Verwendungszweck: SLFN11 Antibody / Schlafen family member 11

Aufreinigung: Affinity purified

Immunogen: An E. coli-derived human protein (amino acids P114-D794) was used as the immunogen for the SLFN11 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SLFN11 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SLFN11 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SLFN11

Target: SLFN11 (Schlafen Family Member 11 (SLFN11))

Andere Bezeichnung: SLFN11

Hintergrund: Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene. SLFN11 is a nuclear protein that belongs to the Schlafen (SLFN) family of genes involved in cell cycle regulation and growth inhibition. Expression of SLFN11 predicts sensitivity of cancer cell lines to DNA-damaging agents. Evidence suggests that in the presence of DNA-targeted therapies, SLFN11 is recruited to stressed replication forks where it blocks replication leading to cell death. SLFN11 is being explored as a predictive biomarker for response to DNA-targeted therapies.

UniProt: Q7Z7L1