STK16 Antikörper (AA 109-268)

Produktnummer ABIN7870054

Der Kaninchen Polyklonal anti-STK16 Antikörper (ABIN7870054) detektiert spezifisch STK16 in WB, ELISA, IHC und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für STK16 Antikörper (AA 109-268) (ABIN7870054)

Target: STK16 (serine/threonine Kinase 16 (STK16))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STK16 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-STK16 Antikörper

Bindungsspezifität: AA 109-268

Verwendungszweck: STK16 Antibody / Serine/threonine-protein kinase 16

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human STK16 recombinant protein (Position: E109-L268) was used as the immunogen for the STK16 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the STK16 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the STK16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu STK16

Target: STK16 (serine/threonine Kinase 16 (STK16))

Andere Bezeichnung: STK16

Hintergrund: STK16 antibody detects Serine/threonine-protein kinase 16, a membrane-associated kinase that regulates secretion, Golgi organization, and intracellular trafficking. The UniProt recommended name is Serine/threonine-protein kinase 16 (STK16). This constitutively active kinase associates with the Golgi apparatus and modulates vesicular transport between the Golgi and plasma membrane.

Functionally, STK16 antibody identifies a 305-amino-acid protein with a typical serine/threonine kinase domain and a C-terminal myristoylation site that anchors it to membranes. STK16 phosphorylates various substrates involved in exocytosis, including components of the SNARE complex. It is essential for maintaining Golgi structure, regulating secretion, and coordinating protein sorting within the secretory pathway.

The STK16 gene is located on chromosome 2q31.1 and is ubiquitously expressed, with enrichment in liver, pancreas, and secretory epithelial tissues. STK16i 1/2s kinase activity is regulated by autophosphorylation and membrane association. It also participates in cell cycle progression and polarized transport, suggesting broader roles in organelle biogenesis and signal transduction.

Pathologically, aberrant STK16 function has been implicated in tumorigenesis, metabolic disease, and Golgi stress. Overexpression may enhance secretion and proliferation, while inhibition disrupts vesicular trafficking and protein glycosylation. Research using STK16 antibody contributes to understanding kinase-mediated control of membrane traffic and its implications in disease and cellular physiology.

STK16 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to visualize Golgi-associated kinases and phosphorylation-dependent trafficking. NSJ Bioreagents offers STK16 antibody reagents optimized for studies of secretion, Golgi function, and signal transduction.

Structurally, STK16 belongs to the NAK (Numb-associated kinase) family and features an N-lobe typical of protein kinases, with regulatory elements that stabilize its constitutive activity. This antibody supports detailed characterization of STK16's role in kinase signaling and Golgi organization.

UniProt: O75716