LLGL2 Antikörper (AA 102-553)

Produktnummer ABIN7869919

Der Kaninchen Polyklonal anti-LLGL2 Antikörper (ABIN7869919) detektiert spezifisch LLGL2 in WB, ELISA und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für LLGL2 Antikörper (AA 102-553) (ABIN7869919)

Target: LLGL2 (Lethal Giant Larvae Homolog 2 (LLGL2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LLGL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-LLGL2 Antikörper

Bindungsspezifität: AA 102-553

Verwendungszweck: LLGL2 Antibody / Lethal giant larvae homolog 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human LLGL2 recombinant protein (Position: L102-Q553) was used as the immunogen for the LLGL2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the LLGL2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the LLGL2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu LLGL2

Target: LLGL2 (Lethal Giant Larvae Homolog 2 (LLGL2))

Andere Bezeichnung: LLGL2

Hintergrund: LLGL2 antibody detects Lethal giant larvae homolog 2, encoded by the LLGL2 gene. Lethal giant larvae homolog 2 is a cytoskeletal and polarity-associated protein that regulates cell polarity, asymmetric cell division, and epithelial organization. LLGL2 antibody provides researchers with a specific reagent for investigating epithelial biology, polarity regulation, and tumor progression.

Lethal giant larvae homolog 2 is a mammalian homolog of the Drosophila tumor suppressor lethal giant larvae, which was first identified as a critical determinant of apical-basal polarity. Research using LLGL2 antibody has demonstrated that LLGL2 contributes to the establishment and maintenance of polarity complexes by interacting with Scribble and Discs large proteins. These interactions ensure spatial organization of epithelial cells, maintaining tissue integrity and function.

Studies with LLGL2 antibody have revealed that it also regulates vesicle trafficking and exocytosis. LLGL2 interacts with SNARE proteins and the exocyst complex to control delivery of polarity proteins and growth factors to the plasma membrane. This vesicular trafficking role integrates with its polarity-regulating function, emphasizing its importance in epithelial biology.

Dysregulation of LLGL2 has been implicated in cancer. Research using LLGL2 antibody has shown that loss or reduction of LLGL2 expression correlates with disruption of cell polarity and increased invasiveness in breast and gastric cancers. Conversely, certain tumors exploit LLGL2 to promote growth factor recycling, supporting proliferation and survival. This dual role underscores the complexity of LLGL2 in tumor biology.

LLGL2 antibody is commonly used in immunohistochemistry, immunofluorescence, and western blotting. Immunohistochemistry highlights reduced expression in cancer tissues, immunofluorescence demonstrates localization to the basolateral membrane, and western blotting quantifies expression across tissues. These approaches make LLGL2 antibody valuable for polarity and cancer research.

By supplying validated LLGL2 antibody reagents, NSJ Bioreagents supports studies into polarity regulation, epithelial biology, and tumorigenesis. Detection of Lethal giant larvae homolog 2 provides researchers with insight into how polarity proteins maintain tissue integrity and influence cancer progression.

UniProt: Q6P1M3

Pathways: WNT Signalweg