Rekombinanter PRAME Antikörper (AA 100-509)

Produktnummer ABIN7869879

Der Kaninchen Monoklonal anti-PRAME Antikörper wird verwendet zum Nachweis von PRAME in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Rekombinanter PRAME Antikörper (AA 100-509) (ABIN7869879)

Target: PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PRAME Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: PRAME-8558R

Produktdetails anti-PRAME Antikörper

Bindungsspezifität: AA 100-509

Verwendungszweck: PRAME Antibody / OIP-4

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 100-509) from the human protein was used as the immunogen for the PRAME antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PRAME antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the PRAME antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu PRAME

Target: PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))

Andere Bezeichnung: PRAME

Hintergrund: Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.

UniProt: P78395

Pathways: Retinoic Acid Receptor Signaling Pathway, Nuclear Hormone Receptor Binding