CD276 Antikörper (AA 100-300)

Produktnummer ABIN7869825

Der Maus Monoklonal anti-CD276 Antikörper wird verwendet zum Nachweis von CD276 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für CD276 Antikörper (AA 100-300) (ABIN7869825)

Target: CD276

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD276 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: B7H3-4345

Produktdetails anti-CD276 Antikörper

Bindungsspezifität: AA 100-300

Verwendungszweck: CD276 Antibody / B7-H3

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 100-300 from the human CD276 protein was used as the immunogen for the CD276 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CD276 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the CD276 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu CD276

Target: CD276

Andere Bezeichnung: CD276

Hintergrund: T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2 and CD276) belongs to the B7 immunoglobulin superfamily. Soluble B7-H3/CD276 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, it costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3/CD276 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3/CD276 as a potential therapeutic tool.

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints