PRAME Antikörper (AA 100-250)
Kurzübersicht für PRAME Antikörper (AA 100-250) (ABIN7869792)
Target
Alle PRAME Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Güteklasse
Klon
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Bindungsspezifität
- AA 100-250
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Verwendungszweck
- PRAME Antibody / OIP-4 (azide and preservative free)
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Aufreinigung
- Protein A/G affinity
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Immunogen
- A recombinant fragment (within amino acids 100-250) of human PRAME protein was used as the immunogen for the PRAME antibody.
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Isotyp
- IgG2b, kappa
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anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 416-502) antibody
PRAME Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 1-509) antibodyPRAME Reaktivität: Human WB, IP, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 151-250) antibodyPRAME Reaktivität: Human, Maus ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 1-509) antibodyPRAME Reaktivität: Human IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 476-502), (C-Term) antibodyPRAME Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB18763 unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 1-509) antibodyPRAME Reaktivität: Human WB Wirt: Maus Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) antibodyPRAME Reaktivität: Human WB, FACS Wirt: Kaninchen Monoclonal 25GB4420 unconjugated Recombinant Antibody
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 416-502) antibodyPRAME Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 460-510) antibodyPRAME Reaktivität: Human, Rind (Kuh), Pferd, Affe, Hund WB Wirt: Kaninchen Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (N-Term) antibodyPRAME Reaktivität: Human, Ratte, Rind (Kuh), Schwein, Affe WB Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- Optimal dilution of the PRAME antibody should be determined by the researcher.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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Konservierungsmittel
- Azide free
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the PRAME antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))
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Andere Bezeichnung
- PRAME
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Hintergrund
- Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
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UniProt
- P78395
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Pathways
- Retinoic Acid Receptor Signaling Pathway, Nuclear Hormone Receptor Binding
Target
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