VCP Antikörper (AA 10-512)

Produktnummer ABIN7869711

Der Kaninchen Polyklonal anti-VCP Antikörper wird verwendet zum Nachweis von VCP in Proben von Human, Maus, Ratte und Affe. Er wurde validiert für WB, ELISA, FACS und IHC (p).

Kurzübersicht für VCP Antikörper (AA 10-512) (ABIN7869711)

Target: VCP (Valosin Containing Protein (VCP))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VCP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-VCP Antikörper

Bindungsspezifität: AA 10-512

Verwendungszweck: TER ATPase Antibody / VCP / Valosin-containing protein

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids D10-K512) was used as the immunogen for the TER ATPase antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TER ATPase antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the TER ATPase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu VCP

Target: VCP (Valosin Containing Protein (VCP))

Andere Bezeichnung: TER ATPase

Hintergrund: Valosin-containing protein also called CDC48 is an enzyme that in humans is encoded by the VCP gene. It is a member of the AAA+ (ATPase associated with various activities) protein family. The VCP gene maps to chromosome 9p13.3. It is necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. It is involved in the formation of the transitional endoplasmic reticulum. This gene plays a role in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites.

UniProt: P55072

Pathways: ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway