ARHGEF12 Antikörper (AA 10-1426)

Produktnummer ABIN7869682

Der Kaninchen Polyklonal anti-ARHGEF12 Antikörper (ABIN7869682) detektiert spezifisch ARHGEF12 in ELISA, WB, IF, IP, IHC (p) und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für ARHGEF12 Antikörper (AA 10-1426) (ABIN7869682)

Target: ARHGEF12 (rho Guanine Nucleotide Exchange Factor (GEF) 12 (ARHGEF12))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARHGEF12 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-ARHGEF12 Antikörper

Bindungsspezifität: AA 10-1426

Verwendungszweck: ARHGEF12 Antibody / LARG

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids 10-1426) was used as the immunogen for the ARHGEF12 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ARHGEF12 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the ARHGEF12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ARHGEF12

Target: ARHGEF12 (rho Guanine Nucleotide Exchange Factor (GEF) 12 (ARHGEF12))

Andere Bezeichnung: ARHGEF12

Hintergrund: ARHGEF12, also known as leukemia-associated Rho guanine nucleotide exchange factor or LARG, is a member of the RhoGEF family involved in the regulation of Rho GTPases. These small signaling proteins are crucial for controlling a variety of cellular processes, including cytoskeletal dynamics, cell polarity, migration, and transcriptional activity. ARHGEF12 acts as a guanine nucleotide exchange factor that specifically activates RhoA, linking it to G protein-coupled receptor signaling pathways and other upstream stimuli.

ARHGEF12 is widely expressed in multiple tissue types and has been implicated in various physiological and pathological conditions, such as embryonic development, wound healing, and cancer progression. Alternative splicing of the ARHGEF12 gene gives rise to several isoforms that may vary in function and cellular localization, making precise detection and characterization essential in research.

A high-quality ARHGEF12 antibody is a critical tool for investigating the diverse roles of this protein in cellular signaling and disease. The ARHGEF12 antibody can be used in western blotting to evaluate protein levels, in immunofluorescence to assess subcellular localization, and in immunohistochemistry for tissue-specific expression profiling. NSJ Bioreagents offers an extensively validated ARHGEF12 antibody designed to provide specificity and reproducibility across multiple experimental platforms.

UniProt: Q9NZN5

Pathways: Neurotrophin Signalübertragung, Regulation of G-Protein Coupled Receptor Protein Signaling