ARHGEF12 Antikörper (AA 1350-1400)

Produktnummer ABIN7452892

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ARHGEF12 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für ARHGEF12 Antikörper (AA 1350-1400) (ABIN7452892)

Target: ARHGEF12 (rho Guanine Nucleotide Exchange Factor (GEF) 12 (ARHGEF12))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARHGEF12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ARHGEF12 Antikörper

Bindungsspezifität: AA 1350-1400

Verwendungszweck: Rabbit anti-LARG Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 1350 and 1400

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: Not recommended. Use rabbit anti-LARG antibody ABIN7451849.

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu ARHGEF12

Target: ARHGEF12 (rho Guanine Nucleotide Exchange Factor (GEF) 12 (ARHGEF12))

Andere Bezeichnung: LARG

Hintergrund: Background: LARG (leukemia-associated RhoGEF) is homologous to PDZ-RhoGEF and functions as a RhoA-specific guanine nucleotide exchange factor. RhoGEFs catalyze the exchange of GDP for GTP on the GTPase, Rho, to activate downstream signaling pathways. LARG contains a PDZ [post synaptic density protein (PSD95), Drosophila discs-large tumor suppressor (DIgA), and zonula occludens-1 protein (zo-1)] domain which is an 80-90 amino acid structural domain found in signaling proteins in bacteria, yeast, plants, and animals. LARG is proposed to play a role in cell polarity and microtubule dynamics and may act as a GTPase-activating protein (GAP) for the heterotrimeric Galpha(12) and Galpha(13) proteins.

Gen-ID: 23365

NCBI Accession: NP_056128

UniProt: Q9NZN5

Pathways: Neurotrophin Signalübertragung, Regulation of G-Protein Coupled Receptor Protein Signaling