Dystrobrevin beta Antikörper (AA 1-627)

Produktnummer ABIN7869507

Der Kaninchen Polyklonal anti-Dystrobrevin beta Antikörper wird verwendet zum Nachweis von Dystrobrevin beta in Proben von Human, Ratte und Maus. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für Dystrobrevin beta Antikörper (AA 1-627) (ABIN7869507)

Target: Dystrobrevin beta (DTNB) (Dystrobrevin, beta (DTNB))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Dystrobrevin beta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-Dystrobrevin beta Antikörper

Bindungsspezifität: AA 1-627

Verwendungszweck: DTNB Antibody / Dystrobrevin beta

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human DTNB recombinant protein (Position: M1-G627) was used as the immunogen for the DTNB antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the DTNB antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the DTNB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Dystrobrevin beta

Target: Dystrobrevin beta (DTNB) (Dystrobrevin, beta (DTNB))

Andere Bezeichnung: DTNB

Hintergrund: DTNB antibody detects Dystrobrevin beta, a cytoplasmic scaffolding protein that associates with dystrophin and syntrophin complexes at the plasma membrane. DTNB participates in maintaining membrane stability, signal transduction, and cytoskeletal anchoring in muscle and neuronal tissues. The DTNB antibody is widely used in muscle biology, neuroscience, and membrane research to study dystrophin-associated complexes and neuromuscular organization.

DTNB is encoded by the DTNB gene located on human chromosome 2p16.2. The protein is approximately 628 amino acids in length and shares structural similarity with dystrobrevin alpha. DTNB localizes to the cytoplasmic face of the sarcolemma and interacts with dystrophin, syntrophins, and other adaptor proteins within the dystrophin-glycoprotein complex (DGC), which links the cytoskeleton to the extracellular matrix.

The DTNB antibody detects a 70 kilodalton protein by western blot and reveals sarcolemmal and cytoplasmic localization under immunofluorescence microscopy. In skeletal muscle, DTNB contributes to stabilization of muscle fibers and transmission of mechanical force. In neurons, it participates in postsynaptic density organization and signal transduction, influencing synaptic plasticity and neurotransmission.

Dysfunction or loss of DTNB disrupts DGC integrity, leading to impaired muscle contractility and signaling abnormalities. Variants in DTNB have been associated with neuromuscular diseases, cognitive deficits, and cardiomyopathy. Through its scaffolding functions, DTNB regulates localization of signaling molecules such as nitric oxide synthase and kinases involved in muscle adaptation.

Because of its role in linking the cytoskeleton to membrane signaling complexes, DTNB provides insights into muscular dystrophy mechanisms and synaptic organization. NSJ Bioreagents provides a validated DTNB antibody optimized for its applications, supporting research into muscle integrity, neuronal communication, and cytoskeletal scaffolding.

UniProt: O60941