MYB Antikörper (AA 1-590)

Produktnummer ABIN7869488

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MYB in WB. Es zeigt Reaktivität gegenüber Proben von Zebrafisch (Danio rerio).

Kurzübersicht für MYB Antikörper (AA 1-590) (ABIN7869488)

Target: MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MYB Antikörper

Bindungsspezifität: AA 1-590

Verwendungszweck: Zebrafish c-Myb Antibody / Myb

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish C-myb recombinant protein (amino acids M1-I590) was used as the immunogen for the Zebrafish C-myb antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish C-myb antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish C-myb antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MYB

Target: MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))

Andere Bezeichnung: c-Myb

Hintergrund: C-Myb is a transcription factor that plays a critical role in the regulation of gene expression during the development and maintenance of hematopoietic stem and progenitor cells. In zebrafish, c-Myb is essential for the formation of definitive blood cells and is widely used as a marker of early hematopoiesis.

During zebrafish embryogenesis, c-Myb is expressed in the dorsal aorta, where hematopoietic stem cells first emerge, as well as in the developing thymus and other hematopoietic tissues. It regulates the expression of genes involved in cell proliferation, differentiation, and survival. Loss of c-Myb function leads to defects in blood cell development, particularly in the production of lymphoid and myeloid lineages.

Due to its conserved function in vertebrate hematopoiesis, zebrafish c-Myb is commonly used in research focused on blood development, leukemia, stem cell biology, and gene regulation. Its accessibility in zebrafish models allows for detailed in vivo studies of hematopoietic disorders and drug screening applications.

UniProt: F1QP25

Pathways: Chromatin Binding, Positive Regulation of Immune Effector Process