MYB Antikörper (Sumoylation Site)

Produktnummer ABIN389068

Produktdetails anti-MYB Antikörper

Target: MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))

Bindungsspezifität: AA 506-534, Sumoylation Site

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Myb Sumoylation Site antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 amino acids from human Myb Sumoylation Site.

Klon: RB2559

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.

Haltbarkeit: 6 months

Details zu MYB

Target: MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))

Andere Bezeichnung: Myb (MYB Produkte)

Synonyme: Cmyb antikoerper, c-myb antikoerper, c-myb_CDS antikoerper, efg antikoerper, AI550390 antikoerper, M16449 antikoerper, cmyb antikoerper, xmyb antikoerper, MYB proto-oncogene, transcription factor antikoerper, myeloblastosis oncogene antikoerper, MYB proto-oncogene, transcription factor S homeolog antikoerper, v-myb avian myeloblastosis viral oncogene homolog antikoerper, MYB antikoerper, Myb antikoerper, myb.S antikoerper, myb antikoerper

Hintergrund: Myb is a transcriptional activator, DNA-binding protein that recognizes the sequence 5'-YAAC[GT]G-3'. It participates in the control of proliferation and differentiation of hematopoietic progenitor cells. Myb is a transcription factor related to Myc, and is expressed predominantly in haematopoietic cells and immature gastroepithelial cells. TRAF7 stimulates the sumoylation of Myb at Lys-523 and Lys-499, which are the same sites as those used for PIASy-induced sumoylation. A correlation has been established between reduction in sumoylation of Myb and increase in transcriptional activation. Negative influence on transactivation properties by the negative regulatory domain region of c-Myb depends on upon sumoylation.

Molekulargewicht: 72341

NCBI Accession: NP_001123644, NP_001123645, NP_001155128, NP_001155129, NP_001155130, NP_001155131, NP_001155132, NP_005366

UniProt: P10242

Pathways: Chromatin Binding, Positive Regulation of Immune Effector Process