PPARG Antikörper (AA 1-512)

Produktnummer ABIN7869446

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PPARG in WB. Es zeigt Reaktivität gegenüber Proben von Zebrafisch (Danio rerio).

Kurzübersicht für PPARG Antikörper (AA 1-512) (ABIN7869446)

Target: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPARG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PPARG Antikörper

Bindungsspezifität: AA 1-512

Verwendungszweck: Zebrafish Ppar gamma Antibody / Pparg

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Ppar gamma recombinant protein (amino acids M1-D512) was used as the immunogen for the Zebrafish Ppar gamma antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Ppar gamma antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Ppar gamma antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PPARG

Target: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Andere Bezeichnung: Ppar gamma

Hintergrund: Pparg (Peroxisome proliferator-activated receptor gamma) is a critical transcription factor that belongs to the nuclear receptor superfamily. It plays a vital role in regulating lipid metabolism, glucose homeostasis, inflammation, and adipocyte differentiation. As a ligand-activated transcription factor, Pparg regulates the expression of genes involved in a variety of physiological processes, including energy metabolism, insulin sensitivity, and immune response. Pparg is activated by fatty acids and other lipid metabolites, making it a key regulator of metabolic homeostasis.

In zebrafish, Pparg is an ortholog of the human PPARG gene. The zebrafish and human proteins share a high degree of sequence conservation, particularly in their DNA binding domain and ligand-binding domain, which are essential for their function as transcription factors. This evolutionary conservation suggests that the role of Pparg in regulating lipid metabolism and adipogenesis is preserved across species, making zebrafish a valuable model for studying the molecular mechanisms of metabolic diseases and obesity.

Pparg in zebrafish has isoforms, which may exhibit tissue-specific expression and functional variation. The existence of isoforms allows for regulation of different target genes depending on developmental stages, tissue types, and environmental conditions. These isoforms may also be involved in regulating distinct physiological processes, such as fatty acid metabolism, inflammatory response, and immune cell differentiation.

In zebrafish, Pparg is expressed in various tissues, including the adipose tissue, liver, and muscles, as well as in developing embryos. Its expression is tightly regulated to ensure proper energy homeostasis and organ development. Pparg plays an essential role in early development, especially in regulating the formation of adipocytes (fat cells), which are important for long-term energy storage and regulation. Disruption of Pparg function in zebrafish can result in defects in lipid metabolism and adipogenesis, providing a model for studying metabolic disorders.

UniProt: A6XMH6

Pathways: MAPK Signalweg, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation