PPP1R12A Antikörper (AA 1-40)

Produktnummer ABIN7869302

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PPP1R12A in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Zebrafisch (Danio rerio).

Kurzübersicht für PPP1R12A Antikörper (AA 1-40) (ABIN7869302)

Target: PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP1R12A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-PPP1R12A Antikörper

Bindungsspezifität: AA 1-40

Verwendungszweck: Zebrafish Ppp1r12a Antibody / Mypt1

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Ppp1r12a recombinant protein (amino acids M1-D40) was used as the immunogen for the Zebrafish Ppp1r12a antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Ppp1r12a antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Ppp1r12a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PPP1R12A

Target: PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))

Andere Bezeichnung: Ppp1r12a

Hintergrund: Ppp1r12a, or protein phosphatase one regulatory subunit twelve a, is a regulatory protein that controls the activity of protein phosphatase one, a major serine threonine phosphatase involved in numerous cellular processes. In zebrafish, Ppp1r12a plays a critical role in regulating cytoskeletal organization, cell contractility, and morphogenesis during development.

Zebrafish Ppp1r12a is the ortholog of the human PPP1R12A gene, which encodes the protein also known as myosin phosphatase target subunit one. This protein directs protein phosphatase one to myosin light chains and other cytoskeletal targets, enabling dynamic control of actomyosin contraction and cell movement. It is involved in signaling pathways that govern smooth muscle relaxation, cell shape changes, and cell migration.

During zebrafish development, Ppp1r12a is expressed in tissues undergoing active morphogenetic movements and structural rearrangement, such as the developing somites, neural tube, and heart. It contributes to proper tissue organization by regulating the phosphorylation state of cytoskeletal components and by modulating mechanical tension within cells.

Disruption of Ppp1r12a function in zebrafish has been shown to affect cell adhesion, motility, and organ formation, highlighting its importance in developmental processes. Due to its conservation across vertebrates and its central role in regulating phosphatase activity, zebrafish Ppp1r12a is a useful model for studying signal transduction, cytoskeletal regulation, and developmental disorders involving cell morphology and contractility.

UniProt: Q6DRG7

Pathways: M Phase