MAP3K2 Antikörper (AA 1-364)

Produktnummer ABIN7869256

Der Kaninchen Polyklonal anti-MAP3K2 Antikörper (ABIN7869256) detektiert spezifisch MAP3K2 in WB, ELISA und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Ratte.

Kurzübersicht für MAP3K2 Antikörper (AA 1-364) (ABIN7869256)

Target: MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP3K2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-MAP3K2 Antikörper

Bindungsspezifität: AA 1-364

Verwendungszweck: MEKK2 Antibody

Aufreinigung: Affinity purified

Immunogen: A human recombinant partial protein (amino acids M1-Q364) was used as the immunogen for the MEKK2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MEKK2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the MEKK2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MAP3K2

Target: MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2))

Andere Bezeichnung: MEKK2

Hintergrund: MAP3K2, mitogen-activated protein kinase kinase kinase 2, also known as MEKK2, belongs to the mitogen-activated protein kinase (MAPK) kinase kinase gene family, which is involved in regulating multiple MAPK signaling pathways. Endogenous MAP3K2 localized mainly to the cytosol of unstimulated HeLa cells and rat fibroblasts. The MAP3K2 gene is mapped to chromosome 2 by the International Radiation Hybrid Mapping Consortium. MAP3K2 is a major upstream activator of the JNK, MAPK cascade. MAP3K2 was identifies as 1 of 6 kinases that regulate different steps of the caveolar cycle. Silencing of MAP3K2 strongly reduced kiss-and-run dynamics, leading to an accumulation of caveolar structures at the cell surface without affecting caveolae coat assembly or clustering.

UniProt: Q9Y2U5

Pathways: MAPK Signalweg