CREB3 Antikörper (AA 1-352)

Produktnummer ABIN7869239

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CREB3 in WB, ELISA und IP. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für CREB3 Antikörper (AA 1-352) (ABIN7869239)

Target: CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CREB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Produktdetails anti-CREB3 Antikörper

Bindungsspezifität: AA 1-352

Verwendungszweck: CREB3 Antibody / Cyclic AMP-responsive element-binding protein 3

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human CREB3 recombinant protein (Position: M1-K352) was used as the immunogen for the CREB3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CREB3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the CREB3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu CREB3

Target: CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))

Andere Bezeichnung: CREB3

Hintergrund: CREB3 antibody detects Cyclic AMP-responsive element-binding protein 3, a transcription factor involved in the unfolded protein response and endoplasmic reticulum (ER) stress regulation. The UniProt recommended name is Cyclic AMP-responsive element-binding protein 3 (CREB3). This ER membrane-bound transcription factor controls gene expression related to protein folding, trafficking, and secretion.

Functionally, CREB3 antibody identifies a 371-amino-acid protein anchored in the ER membrane with a cytoplasmic basic leucine zipper (bZIP) domain. Upon ER stress, the N-terminal transcriptional domain of CREB3 is cleaved and translocated to the nucleus, where it activates target genes involved in secretion and Golgi maintenance. CREB3 also regulates acute phase response genes and collagen biosynthesis.

The CREB3 gene is located on chromosome 9p13.3 and is highly expressed in secretory tissues such as liver, pancreas, and intestine. It plays a central role in adapting to increased secretory load and maintaining ER homeostasis under stress conditions.

Pathologically, dysregulation of CREB3 contributes to metabolic disorders, neurodegeneration, and cancer progression by disturbing ER stress response pathways. Overexpression can enhance tumor invasion by modulating extracellular matrix and stress-related signaling genes. Research using CREB3 antibody supports studies in transcriptional regulation, ER stress, and secretory pathway biology.

CREB3 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect transcription factors and stress response regulators. NSJ Bioreagents provides CREB3 antibody reagents optimized for research in cellular homeostasis, transcription, and disease adaptation.

Structurally, Cyclic AMP-responsive element-binding protein 3 contains a bZIP domain for DNA binding and dimerization, along with a luminal stress-sensing region. This antibody enables investigation of CREB3's role in ER stress signaling and transcriptional control.

UniProt: O43889

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Maintenance of Protein Location, Unfolded Protein Response