Rekombinanter INSM1 Antikörper (AA 1-300)

Produktnummer ABIN7869132

Der Kaninchen Monoklonal anti-INSM1 Antikörper wird verwendet zum Nachweis von INSM1 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Rekombinanter INSM1 Antikörper (AA 1-300) (ABIN7869132)

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser INSM1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: INSM1-8149R

Produktdetails anti-INSM1 Antikörper

Bindungsspezifität: AA 1-300

Verwendungszweck: Insulinoma associated protein 1 Antibody / INSM1 (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-300) from the human protein was used as the immunogen for the Insulinoma associated protein 1 antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Insulinoma associated protein 1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Insulinoma associated protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu INSM1

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Andere Bezeichnung: Insulinoma associated protein 1

Hintergrund: Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95 % of lung small cell carcinoma and 91 % of lung large cell neuroendocrine carcinoma, compared with 75 % and 78 % with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56).INSM1 stains 100 % of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3 % of adenocarcinomas and 4 % of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.

UniProt: Q01101