Rekombinanter INSM1 Antikörper (N-Term)

Produktnummer ABIN7857867

Der Kaninchen Monoklonal anti-INSM1 Antikörper wird verwendet zum Nachweis von INSM1 in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für Rekombinanter INSM1 Antikörper (N-Term) (ABIN7857867)

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser INSM1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: INSM1-6286R

Produktdetails anti-INSM1 Antikörper

Bindungsspezifität: AA 81-125, N-Term

Expressionssystem: HEK-293 Cells

Verwendungszweck: Recombinant INSM1 (Pan-Neuroendocrine Marker) Antibody

Spezifität: Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95 % of lung small cell carcinoma and 91 % of lung large cell neuroendocrine carcinoma, compared with 75 % and 78 % with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56).INSM1 stains 100 % of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3 % of adenocarcinomas and 4 % of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.

Aufreinigung: 200ug/ml of Ab produced in HEK293 cell mammalian-based expression system.

Immunogen: Recombinant fragment (around aa81-125) corresponding to the N-terminus of human INSM1

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu INSM1

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Andere Bezeichnung: INSM1

Hintergrund:

IA1, Insulinoma associated protein 1 (IA1), Zinc finger protein IA1

Human pancreas or neuroendocrine tumor.

Molekulargewicht: 58kDa

Gen-ID: 3642, 89584

UniProt: Q01101