IMPA1 Antikörper (AA 1-277)

Produktnummer ABIN7869035

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch IMPA1 in WB, ELISA, FACS und IP. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für IMPA1 Antikörper (AA 1-277) (ABIN7869035)

Target: IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IMPA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP)

Produktdetails anti-IMPA1 Antikörper

Bindungsspezifität: AA 1-277

Verwendungszweck: IMPA1 Antibody / Inositol monophosphatase 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human IMPA1 recombinant protein (Position: M1-D277) was used as the immunogen for the IMPA1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the IMPA1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the IMPA1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu IMPA1

Target: IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

Andere Bezeichnung: IMPA1

Hintergrund: IMPA1 antibody recognizes Inositol monophosphatase 1, a magnesium-dependent enzyme that catalyzes the dephosphorylation of inositol monophosphate to free inositol, a crucial step in the phosphatidylinositol signaling pathway. The IMPA1 gene encodes a cytosolic enzyme essential for recycling inositol phosphates derived from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). This reaction is critical for maintaining inositol supply for the synthesis of phosphoinositides, which regulate intracellular signaling, neurotransmission, and osmoregulation.

IMPA1 is expressed abundantly in brain, kidney, and liver, reflecting its central role in inositol metabolism. In neurons, IMPA1 supports the phosphoinositide cycle, enabling sustained neurotransmitter signaling via inositol trisphosphate and diacylglycerol pathways. Pharmacologically, IMPA1 is a well-known molecular target of lithium, a mood-stabilizing drug used in the treatment of bipolar disorder. Lithium inhibits IMPA1 activity, leading to inositol depletion and modulation of neuronal signaling, supporting the i 1/2inositol depletion hypothesisi 1/2 for mood stabilization.

The human IMPA1 gene is located on chromosome 8q21.13 and encodes a 277-amino acid protein that functions as a homodimer. The enzyme binds magnesium ions within its active site to hydrolyze phosphate from a range of inositol monophosphate substrates. Structural studies have revealed conserved residues critical for catalysis and lithium binding. Genetic or functional alterations in IMPA1 have been associated with neurological disorders, cognitive deficits, and certain metabolic diseases. Experimental evidence also implicates IMPA1 in maintaining cellular osmotic balance, particularly in renal epithelial cells where inositol acts as a compatible osmolyte.

Immunohistochemical analysis using IMPA1 antibody shows strong cytoplasmic staining in neurons, glial cells, renal tubules, and hepatocytes. The antibody is useful for studying inositol phosphate metabolism, lithium pharmacology, and neuronal signaling pathways. IMPA1 antibody from NSJ Bioreagents supports research into inositol-dependent biochemical networks and the molecular mechanisms underlying psychiatric and neurological disease.

UniProt: P29218