TOLLIP Antikörper (AA 1-274)

Produktnummer ABIN7869030

Der Kaninchen Polyklonal anti-TOLLIP Antikörper wird verwendet zum Nachweis von TOLLIP in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IF, IHC (p) und FACS.

Kurzübersicht für TOLLIP Antikörper (AA 1-274) (ABIN7869030)

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TOLLIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-TOLLIP Antikörper

Bindungsspezifität: AA 1-274

Verwendungszweck: Toll-interacting protein Antibody / TOLLIP

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids M1-P274) was used as the immunogen for the Toll-interacting protein antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Toll-interacting protein antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Toll-interacting protein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu TOLLIP

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Andere Bezeichnung: Toll-interacting protein

Hintergrund: TOLLIP (TOLL-Interacting Protein) is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene. Lo et al.(2009) stated that the TOLLIP gene maps to chromosome 11. The mouse gene maps to chromosome 7. By western blot analysis of embryonic kidney cells, Burns et al.(2000) confirmed the binding of TOLLIP to IL1RAP, to a complex of IL1RAP-IL1R1, and to IL18R. Burns et al.(2000) proposed that IL1B stimulation induces aggregation of IL1Rs, recruitment of MYD88 followed by TOLLIP-IRAK complexes, and the phosphorylation of IRAK by MYD88. This leads to the dissociation of TOLLIP from IRAK, which can then transmit the IL1-induced signals.

UniProt: Q9H0E2