HMMR Antikörper (AA 1-250)

Produktnummer ABIN7868944

Der Maus Monoklonal anti-HMMR Antikörper (Klon HMMR-8021) (ABIN7868944) detektiert spezifisch HMMR in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für HMMR Antikörper (AA 1-250) (ABIN7868944)

Target: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HMMR Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: HMMR-8021

Produktdetails anti-HMMR Antikörper

Bindungsspezifität: AA 1-250

Verwendungszweck: CD168 Antibody / HMMR

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-250) from the human protein was used as the immunogen for the CD168 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CD168 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the CD168 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu HMMR

Target: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Andere Bezeichnung: CD168

Hintergrund: Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan that regulates cell adhesion and migration. HA effects are mediated through two receptors, CD44 (also designated HCAM) and the receptor of hyaluronic acid mediated motility (RHAMM). RHAMM, also designated intracellular hyaluronic acid binding protein (IHABP) and CD168, is a matrix receptor, which is linked to the plasma membrane by a GPI anchor and regulates cell motility. RHAMM expression is upregulated in malignant lymphoid tissues and is subsequently implicated in tumor progression and metastasis formation, as well as signal transduction. Although still unclear, RHAMM is thought to exist as several isoforms ranging in size. A variant isoform, designated v4, is a protein that when over-expressed, is thought to be the cause of transformation and metastasis formation in fibroblasts.

UniProt: O75330

Pathways: Glycosaminoglycan Metabolic Process