NAT15 Antikörper (AA 1-242)

Produktnummer ABIN7868910

Der Kaninchen Polyklonal anti-NAT15 Antikörper wird verwendet zum Nachweis von NAT15 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IHC, IF, ICC und IP.

Kurzübersicht für NAT15 Antikörper (AA 1-242) (ABIN7868910)

Target: NAT15 (N-Acetyltransferase 15 (NAT15))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NAT15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Produktdetails anti-NAT15 Antikörper

Bindungsspezifität: AA 1-242

Verwendungszweck: NAA60 Antibody / N-alpha-acetyltransferase 60

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human NAA60 recombinant protein (Position: M1-M242) was used as the immunogen for the NAA60 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the NAA60 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the NAA60 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu NAT15

Target: NAT15 (N-Acetyltransferase 15 (NAT15))

Andere Bezeichnung: NAA60

Hintergrund: NAA60 antibody detects N-alpha-acetyltransferase 60, a Golgi-associated enzyme responsible for acetylating the N-termini of transmembrane and cytosolic proteins. The UniProt recommended name is N-alpha-acetyltransferase 60 (NAA60). This enzyme belongs to the GNAT (GCN5-related N-acetyltransferase) family and contributes to post-translational protein modification, stability, and membrane targeting.

Functionally, NAA60 antibody identifies a 242-amino-acid acetyltransferase localized to the cytosolic face of the Golgi apparatus. NAA60 catalyzes the transfer of an acetyl group from acetyl-CoA to protein N-termini, particularly targeting lysine residues within membrane-bound substrates. Its unique subcellular localization distinguishes it from other N-terminal acetyltransferases (NATs) acting in the cytosol or nucleus.

The NAA60 gene is located on chromosome 16p13.3 and is broadly expressed in mammalian tissues, with enrichment in epithelial and secretory cells. By modifying transmembrane proteins, NAA60 influences vesicle trafficking, protein sorting, and Golgi membrane organization. It also contributes to cell cycle progression and mitotic spindle stability.

Pathologically, altered NAA60 activity has been linked to cell proliferation abnormalities and tumorigenesis. Reduced NAA60 expression affects Golgi morphology and disrupts intracellular transport. Research using NAA60 antibody supports studies in protein acetylation, Golgi biology, and membrane-associated protein regulation.

NAA60 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect acetyltransferases in cell lysates and subcellular fractions. NSJ Bioreagents provides NAA60 antibody reagents optimized for research in protein modification, trafficking, and cell signaling.

Structurally, N-alpha-acetyltransferase 60 contains a conserved acetyl-CoA-binding motif and catalytic residues typical of GNAT enzymes. This antibody enables investigation of NAA60's functional role in post-translational regulation and Golgi-associated protein processing.

UniProt: Q9H7X0